General Information

    • DRAMP ID

    • DRAMP18273

    • Peptide Name

    • Enterocin CRL35 (Bacteriocin)

    • Source

    • Enterococcus mundtii CRL35

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • munA

    • Sequence

    • KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWKS

    • Sequence Length

    • 43

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antibacterial, Antiviral, Anti-Gram+, Antimicrobial

    • Target Organism

    • Gram-positive, virus(certain)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18273 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18273.

Physicochemical Information

    • Formula

    • C186H291N55O58S2

    • Absent Amino Acids

    • EFHMPQR

    • Common Amino Acids

    • G

    • Mass

    • 4289.81

    • PI

    • 9.45

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • -3182

    • Hydrophobicity

    • -0.254

    • Aliphatic Index

    • 63.72

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 14105

    • Absorbance 280nm

    • 335.83

    • Polar Residues

    • 23

DRAMP18273

DRAMP18273 chydropathy plot

Comments Information

    • Both biological activities, antibacterial and antiviral, were destroyed after incubation of the enterocin with protease IV or by raising the pH.

Literature Information

  • ·Literature 1

    • Title

    • Antiviral activity of enterocin CRL35 against herpesviruses.

    • Reference

    • Int J Antimicrob Agents. 1999 Aug;12(4):293-9.

    • Author

    • Wachsman MB, Far
  • ·Literature 2

    • Title

    • Effect of enterocin CRL35 on Listeria monocytogenes cell membrane.

    • Reference

    • FEMS Microbiol Lett. 2000 Nov 1;192(1):79-83.

    • Author