• DRAMP ID

    • DRAMP18277
    • Peptide Name

    • Halocin C8 (Bacteriocin)
    • Source

    • Halobacterium sp. (strain AS7092)
    • Family

    • Not found
    • Gene

    • proC8
    • Sequence

    • DIDITGCSACKYAAGQVCTIGCSAAGGFICGLLGITIPVAGLSCLGFVEIVCTVADEYSGCGDAVAKEACNRAGLC
    • Sequence Length

    • 76
    • Protein Existence

    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell wall
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • disulphide bridges
    • Structure Description

    • HalC8 contains 10 cysteines that could form disulphide bridges, leading to a little decrease in molecular weight.
    • Helical Wheel Diagram

    • DRAMP18277 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18277.
    • Formula

    • C316H511N83O103S10
    • Absent Amino Acids

    • HMW
    • Common Amino Acids

    • GA
    • Mass

    • 7441.63
    • PI

    • 4.14
    • Basic Residues

    • 3
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 31
    • Net Charge

    • -4
    • Boman Index

    • 1556
    • Hydrophobicity

    • 0.886
    • Aliphatic Index

    • 98.95
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 3605
    • Absorbance 280nm

    • 48.07
    • Polar Residues

    • 33

DRAMP18277

DRAMP18277 chydropathy plot
    • quite stable, can be desalted, boiled, frozen, subjected to organic solvents, and stored in culture supernatant at 4

  • ·Literature 1
    • Title

    • Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.
    • Reference

    • Extremophiles. 2003 Oct;7(5):401-7.
    • Author

    • Li Y, Xiang H, Liu J, Zhou M, Tan H.
  • ·Literature 2
    • Title

    • A single gene directs both production and immunity of halocin C8 in a haloarchaeal strain AS7092.
    • Reference

    • Mol Microbiol. 2005 Jul;57(2):537-49.
    • Author

    • Sun C, Li Y, Mei S, Lu Q, Zhou L, Xiang H.