General Information

    • DRAMP ID

    • DRAMP18279

    • Peptide Name

    • Plantaricin A(Bacteriocin)

    • Source

    • Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

    • Family

    • Belongs to the class IIb bacteriocin

    • Gene

    • plnA

    • Sequence

    • AYSLQMGATAIKQVKKLFKKWGW

    • Sequence Length

    • 23

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Active plantaricin A is composed of an alpha chain and a beta chain. The sequence of alpha chain and beta chain, however, are essential identical with the only difference being one additional Ala at the N-terminus of chain b. The 3D structure of chain a in DPC micelles has been determined by NMR spectroscopy (J Biol Chem. 2005 Jun 17;280(24):22945-50). The helical region (residues 12-21) are good for membrane targeting as well as the ph

    • Helical Wheel Diagram

    • DRAMP18279 helical wheel diagram

    • PDB ID

    • 1YTR resolved by NMR

    • Predicted Structure

    • There is no predicted structure for DRAMP18279.

Physicochemical Information

    • Formula

    • C128H200N32O29S

    • Absent Amino Acids

    • CDEHNPR

    • Common Amino Acids

    • K

    • Mass

    • 2683.25

    • PI

    • 10.3

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • -884

    • Hydrophobicity

    • -0.239

    • Aliphatic Index

    • 76.52

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 12490

    • Absorbance 280nm

    • 567.73

    • Polar Residues

    • 5

DRAMP18279

DRAMP18279 chydropathy plot

Comments Information

    • Active plantaricin A is composed of an alpha chain and a beta chain.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides.

    • Reference

    • J Gen Microbiol. 1993 Sep;139(9):1973-8.

    • Author

    • Nissen-Meyer J, Larsen AG, Sletten K, Daeschel M, Nes IF.