General Information

    • DRAMP ID

    • DRAMP18295

    • Peptide Name

    • Leucocin H alpha(Bacteriocin)

    • Source

    • Leuconostoc MF215B

    • Family

    • Belongs to the class IIb bacteriocin

    • Gene

    • Not found

    • Sequence

    • WXIGVTGAALGTGKGVKNVI

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • No sequence homology to other known bacteriocins could be demonstrated. It also appeared that the two peptides themselves shared little or no sequence homology.

    • Helical Wheel Diagram

    • DRAMP18295 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18295.

Physicochemical Information

    • Formula

    • C84H139N23O22

    • Absent Amino Acids

    • CDEFHMPQRSY

    • Common Amino Acids

    • G

    • Mass

    • 1952.51

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 1465

    • Hydrophobicity

    • 0.67

    • Aliphatic Index

    • 112

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 289.47

    • Polar Residues

    • 8

DRAMP18295

DRAMP18295 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Characterization, production, and purification of leucocin H, a two-peptide bacteriocin from Leuconostoc MF215B.

    • Reference

    • Curr Microbiol. 1999 Jul;39(1):43-8.

    • Author

    • Blom H, Katla T, Holck A, Sletten K, Axelsson L, Holo H.