General Information

    • DRAMP ID

    • DRAMP18298

    • Peptide Name

    • Listeriolysin S(Bacteriocin)

    • Source

    • Listeria monocytogenes F2365

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • CCSCSCSTCTCTCTCASSAATKM

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18298 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18298.

Physicochemical Information

    • Formula

    • C79H138N24O34S9

    • Absent Amino Acids

    • DEFGHILNPQRVWY

    • Common Amino Acids

    • C

    • Mass

    • 2256.65

    • PI

    • 7.7

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -1738

    • Hydrophobicity

    • 0.691

    • Aliphatic Index

    • 13.04

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 500

    • Absorbance 280nm

    • 22.73

    • Polar Residues

    • 18

DRAMP18298

DRAMP18298 chydropathy plot

Comments Information

    • Comment

    • A haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen. This haemolysin is only induced under oxidative stress conditions and contributes to murine virulence and in survival in polymorphonuclear neutrophils.

Literature Information

  • ·Literature 1

    • Title

    • Listeriolysin S, a novel peptide haemolysin associated with a subset of lineage I Listeria monocytogenes.

    • Reference

    • PLoS Pathog. 2008 Sep 12;4(9):e1000144.

    • Author

    • Cotter PD, Draper LA, Lawton EM, Daly KM, Groeger DS, Casey PG, Ross RP, Hill C.