General Information

    • DRAMP ID

    • DRAMP18299

    • Peptide Name

    • Taromycin A (Bacteriocin)

    • Source

    • marine actinomycete Saccharomonospora sp. CNQ-490

    • Family

    • Belongs to the lipopeptides family

    • Gene

    • Not found

    • Sequence

    • WNDTGKDADGAEY

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Taromycin A differs from Daptomycin only in serveal places: 1) residue T11 is an D-Ala; 2) W is chlorinated at position 6; 3) Kny is also chlorinated at position 4; and 4) it carried an octa-2,4-dienoyl lipid side chain. Warning: the sequence is a close mimic of the natural counterpart. For example, kynurenine-13 (Kyn) is represented by Y here.

    • Helical Wheel Diagram

    • DRAMP18299 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18299.

Physicochemical Information

    • Formula

    • C61H84N16O25

    • Absent Amino Acids

    • CFHILMPQRSV

    • Common Amino Acids

    • D

    • Mass

    • 1441.43

    • PI

    • 3.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 3

    • Net Charge

    • -3

    • Boman Index

    • -4004

    • Hydrophobicity

    • -1.654

    • Aliphatic Index

    • 15.38

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 582.5

    • Polar Residues

    • 5

DRAMP18299

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

    • Reference

    • Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1957-62.

    • Author

    • Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS.