General Information

    • DRAMP ID

    • DRAMP18301

    • Peptide Name

    • nocathiacin I(Bacteriocin)

    • Source

    • Nocardia sp. ATCC202099

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • SCTTCECSCSCSS

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • NOC-I shares the overall similarity in structure to the naturally occurring but un-glycosylated analogue, nosiheptide (NOS). NOC-I is further functionalized by the methoxylation of a dehydrothreonine in the macrocyclic core,N-hydroxylation ofthe indole moiety, rigid constraining of these two systems viaan etherbondinadditiontotwoesterlinkages,andappendingofa rare sugar moiety, 2,4,6-tri-deoxy-3-methyl-4-N,N-dimethylaminoL-hexose.

    • Helical Wheel Diagram

    • DRAMP18301 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18301.

Physicochemical Information

    • Formula

    • C43H73N13O23S5

    • Absent Amino Acids

    • ADFGHIKLMNPQRVWY

    • Common Amino Acids

    • CS

    • Mass

    • 1300.43

    • PI

    • 4

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 0

    • Net Charge

    • -1

    • Boman Index

    • -2255

    • Hydrophobicity

    • 0.277

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 20.83

    • Polar Residues

    • 12

DRAMP18301

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.

    • Reference

    • Mol Biosyst. 2010 Jul;6(7):1180-5.

    • Author

    • Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W.