General Information

    • DRAMP ID

    • DRAMP18302

    • Peptide Name

    • GE2270A(Bacteriocin)

    • Source

    • Nonomuraea

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • SCNCVCGFCCSCSPSA

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Elongation Factor Tu (EF-Tu)

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18302 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18302.

Physicochemical Information

    • Formula

    • C58H91N17O22S6

    • Absent Amino Acids

    • DEHIKLMQRTWY

    • Common Amino Acids

    • C

    • Mass

    • 1570.82

    • PI

    • 5.23

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • -279

    • Hydrophobicity

    • 0.944

    • Aliphatic Index

    • 24.38

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 25

    • Polar Residues

    • 12

DRAMP18302

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Elongation Factor Tu1 of the Antibiotic GE2270A Producer Planobispora rosea Has an Unexpected Resistance Profile against EF-Tu Targeted Antibiotics.

    • Reference

    • BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997 JAN 13;230(2):320-326.

    • Author

    • Mohrle VG,Tieleman LN,Kraal B.