General Information

    • DRAMP ID

    • DRAMP18304

    • Peptide Name

    • Paenicidin A (Bacteriocin)

    • Source

    • Paenibacillus polymyxa NRRL B-30509

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • paeA

    • Sequence

    • VLSIVACSSGCGSGKTAASCVETCGNRCFTNVGSLC

    • Sequence Length

    • 36

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • There are three lanthionines (between residues 3-7; 8-11; 19-24) and three methyllanthionines rings (between residues 16-20; 23-28; 30-36).

    • Helical Wheel Diagram

    • DRAMP18304 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18304.

Physicochemical Information

    • Formula

    • C139H234N42O50S6

    • Absent Amino Acids

    • DHMPQWY

    • Common Amino Acids

    • CS

    • Mass

    • 3486

    • PI

    • 7.75

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +1

    • Boman Index

    • -1696

    • Hydrophobicity

    • 0.675

    • Aliphatic Index

    • 73.06

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 10.71

    • Polar Residues

    • 22

DRAMP18304

DRAMP18304 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy.

    • Reference

    • J Am Chem Soc. 2012 Dec 5;134(48):19540-3.

    • Author

    • Lohans CT, Huang Z, van Belkum MJ, Giroud M, Sit CS, Steels EM, Zheng J, Whittal RM, McMullen LM, Vederas JC.