General Information

    • DRAMP ID

    • DRAMP18305

    • Peptide Name

    • Paenibacterin (Bacteriocin)

    • Source

    • Paenibacillus thiaminolyticus OSY-SE

    • Family

    • Belongs to the lipopeptides family

    • Gene

    • Not found

    • Sequence

    • KVTKSVKSIPVKI

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Broad-spectrum

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • A C15 fatty acid chain is attahced to the N-terminus of the peptide (XXL). The carboxyl-terminal Ile is connected to Thr by ester linkage (XXJ). In addition, the first and fourth K's are ornithine (represented with K).

    • Helical Wheel Diagram

    • DRAMP18305 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18305.

Physicochemical Information

    • Formula

    • C66H123N17O17

    • Absent Amino Acids

    • ACDEFGHLMNQRWY

    • Common Amino Acids

    • K

    • Mass

    • 1426.81

    • PI

    • 10.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +4

    • Boman Index

    • -961

    • Hydrophobicity

    • 0.162

    • Aliphatic Index

    • 126.92

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18305

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Isolation of a Paenibacillus sp. strain and structural elucidation of its broad-spectrum lipopeptide antibiotic.

    • Reference

    • Appl Environ Microbiol. 2012 May;78(9):3156-65.

    • Author

    • Guo Y, Huang E, Yuan C, Zhang L, Yousef AE.