General Information

    • DRAMP ID

    • DRAMP18307

    • Peptide Name

    • LMW peptide (Bacteriocin)

    • Source

    • Pediococcus pentosaceus IE-3

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • APVPFSCTRGCLTHLV

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18307 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18307.

Physicochemical Information

    • Formula

    • C75H121N21O20S2

    • Absent Amino Acids

    • DEIKMNQWY

    • Common Amino Acids

    • CLPTV

    • Mass

    • 1701.03

    • PI

    • 8.12

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -191

    • Hydrophobicity

    • 0.756

    • Aliphatic Index

    • 91.25

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 8.33

    • Polar Residues

    • 6

DRAMP18307

Comments Information

    • Unlike pediocin-like bacteriocins, the low molecular weight peptide (LMW) showed resistance to different proteases. Moreover, peptide treated with reducing agent like dithiothreitol (DTT) exhibited increased activity against both Gram-positive and Gram-negative test strains in comparison to native peptide. However, peptide treated with oxidizing agent such as hydrogen peroxide (H2O2) did not show any antimicrobial activity.

Literature Information

  • ·Literature 1

    • Title

    • A non-pediocin low molecular weight antimicrobial peptide produced by Pediococcus pentosaceus strain IE-3 shows increased activity under reducing environment.

    • Reference

    • BMC Microbiol. 2014 Aug 27;14:226.

    • Author

    • Singh PK, Sharma S, Kumari A, Korpole S.