General Information

    • DRAMP ID

    • DRAMP18309

    • Peptide Name

    • Baceridin(Bacteriocin)

    • Source

    • plant-associated Bacillus strain

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WAIVLL

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive(weakly)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • A circular peptide where residues 2, 3, and 5 are D-amino acids.

    • Helical Wheel Diagram

    • DRAMP18309 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18309.

Physicochemical Information

    • Formula

    • C37H59N7O7

    • Absent Amino Acids

    • CDEFGHKMNPQRSTY

    • Common Amino Acids

    • L

    • Mass

    • 713.92

    • PI

    • 5.52

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • 2294

    • Hydrophobicity

    • 2.867

    • Aliphatic Index

    • 260

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 1100

    • Polar Residues

    • 0

DRAMP18309

Comments Information

    • Baceridin was tested for antimicrobial and cytotoxic activity and displayed moderate cytotoxicity (1

Literature Information

  • ·Literature 1

    • Title

    • Baceridin, a cyclic hexapeptide from an epiphytic bacillus strain, inhibits the proteasome.

    • Reference

    • Chembiochem. 2014 May 5;15(7):1021-9.

    • Author

    • Niggemann J, Bozko P, Bruns N, Wodtke A, Gieseler MT, Thomas K, Jahns C, Nimtz M, Reupke I, Br