General Information
-
DRAMP ID
- DRAMP18310
-
Peptide Name
- Patellamide A(Bacteriocin)
-
Source
- Prochloron didemni
-
Family
- Belongs to the class I bacteriocin
-
Gene
- patE
-
Sequence
- ITVCISVC
-
Sequence Length
- 8
-
UniProt Entry
- No entry found
-
Protein Existence
Activity Information
-
Biological Activity
- Unknown
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18310.
Physicochemical Information
-
Formula
- C35H64N8O11S2
Absent Amino Acids
- ADEFGHKLMNPQRWY
Common Amino Acids
- CIV
Mass
- 837.06
PI
- 5.51
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- 0
-
Boman Index
- 1451
Hydrophobicity
- 2.613
Aliphatic Index
- 170
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 17.86
Polar Residues
- 4
DRAMP18310
Comments Information
Before both peptides, there is a 5-aa conserved region consisting of the consensus G(LV)E(AP)S. The sequence AYDGE terminates the patellamide A sequence and directly precedes the stop codon. Between the two patellamides, the 8-aa sequence AYDGVEPS seems to encode for both a start and stop cyclization sequence, with the consensus stop sequence being AYDG(EV).
Literature Information
- ·Literature 1
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Title
- Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.
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Pubmed ID
- 15883371
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Reference
- Proc Natl Acad Sci U S A. 2005 May 17;102(20):7315-20.
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Author
- Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood MG, Ravel J.