General Information

    • DRAMP ID

    • DRAMP18311

    • Peptide Name

    • Patellamide C(Bacteriocin)

    • Source

    • Prochloron didemni

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • patE

    • Sequence

    • VTACITFC

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18311 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18311.

Physicochemical Information

    • Formula

    • C37H60N8O11S2

    • Absent Amino Acids

    • DEGHKLMNPQRSWY

    • Common Amino Acids

    • CT

    • Mass

    • 857.05

    • PI

    • 5.48

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • 0

    • Boman Index

    • 1117

    • Hydrophobicity

    • 2.113

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 17.86

    • Polar Residues

    • 4

DRAMP18311

Comments Information

    • Before both peptides, there is a 5-aa conserved region consisting of the consensus G(LV)E(AP)S. The sequence AYDGE terminates the patellamide A sequence and directly precedes the stop codon. Between the two patellamides, the 8-aa sequence AYDGVEPS seems to encode for both a start and stop cyclization sequence, with the consensus stop sequence being AYDG(EV).

Literature Information

  • ·Literature 1

    • Title

    • Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella.

    • Reference

    • Proc Natl Acad Sci U S A. 2005 May 17;102(20):7315-20.

    • Author

    • Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood MG, Ravel J.