General Information

    • DRAMP ID

    • DRAMP18313

    • Peptide Name

    • Sclerosin(Bacteriocin)

    • Source

    • Pseudomonas sp. strain DF41

    • Family

    • Belongs to the lipopeptides family

    • Gene

    • Not found

    • Sequence

    • TPALAVVTTVLPAAAVTTAKSV

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Warning: this peptide contains non-natural amino acids although they are represented using the closest standard 20 amino acids. Specifically, T1, T8, T17, and T18 are dehydrated into Dhb. P12 is 3,4-dehydrated (Dhp). In total, five residues are dehydrated. Residue K20 is Dab (2,4-diaminobutyric acid). Finally, the acyl chain CH(3)-(CH(2))(6)-CH(OH)-CH(2)-CO is attached to the N-terminus. Thus, the entire sequence is CH(3)-(CH(2))(6)-CH

    • Helical Wheel Diagram

    • DRAMP18313 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18313.

Physicochemical Information

    • Formula

    • C94H165N23O29

    • Absent Amino Acids

    • CDEFGHIMNQRWY

    • Common Amino Acids

    • A

    • Mass

    • 2081.48

    • PI

    • 8.41

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +1

    • Boman Index

    • 1910

    • Hydrophobicity

    • 1.273

    • Aliphatic Index

    • 128.64

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18313

DRAMP18313 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Chemical and biological characterization of sclerosin, an antifungal lipopeptide.

    • Reference

    • Can J Microbiol. 2012 Aug;58(8):1027-34.

    • Author

    • Berry CL, Brassinga AK, Donald LJ, Fernando WG, Loewen PC, de Kievit TR.