General Information

    • DRAMP ID

    • DRAMP18318

    • Peptide Name

    • BacCH91(Bacteriocin)

    • Source

    • Staphylococcus aureus CH-91

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • bacCH91

    • Sequence

    • ITSFIGCTPGCGKTGSFNSFCC

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Similar to Gallidermin and epidermin. The fourth residue was phenylalanine in BacCH91 but lysine in both epidermin and gallidermin, which explains the more hydrophobic character of BacCH91.

    • Helical Wheel Diagram

    • DRAMP18318 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18318.

Physicochemical Information

    • Formula

    • C95H144N24O30S4

    • Absent Amino Acids

    • ADEHLMQRVWY

    • Common Amino Acids

    • CG

    • Mass

    • 2230.57

    • PI

    • 7.88

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +1

    • Boman Index

    • -244

    • Hydrophobicity

    • 0.559

    • Aliphatic Index

    • 35.45

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 11.9

    • Polar Residues

    • 15

DRAMP18318

DRAMP18318 chydropathy plot

Comments Information

    • The bacteriocin was not affected by any of the staphylococcal peptidases tested, particularly StpC. BacCH91 was unaffected by trypsin and proteinase K.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, biochemical characterization, and cloning of a bacteriocin from the poultry-associated Staphylococcus aureus strain CH-91.

    • Reference

    • Appl Microbiol Biotechnol. 2013 Aug;97(16):7229-39.

    • Author

    • Wladyka B, Wielebska K, Wloka M, Bochenska O, Dubin G, Dubin A, Mak P.