General Information

    • DRAMP ID

    • DRAMP18319

    • Peptide Name

    • BsaA2(Bacteriocin)

    • Source

    • Staphylococcus aureus strain 26

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • ITSHSLCTPGCAKTGSFNSFCC

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Tandem MS analysis identified two sequence tags (Dhb-PGCAK/Q-Dhb-G and I/L-Dhb-Dha-H [due to the use of CID, Dha/Dhb represents either a dehydrated amino acid or a site of thioether bridge cleavage]) that matched the deduced amino acid sequence of BsaA2.Thioether bonds between residues 3 and 7, 8-11, 16-21, and 19-22.

    • Helical Wheel Diagram

    • DRAMP18319 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18319.

Physicochemical Information

    • Formula

    • C94H146N26O31S4

    • Absent Amino Acids

    • DEMQRVWY

    • Common Amino Acids

    • CS

    • Mass

    • 2264.59

    • PI

    • 7.9

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -1355

    • Hydrophobicity

    • 0.336

    • Aliphatic Index

    • 40

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 11.9

    • Polar Residues

    • 14

DRAMP18319

DRAMP18319 chydropathy plot

Comments Information

    • This bacteriocin is identical to staphylococcin Au-26 initially reported in 1992.

Literature Information

  • ·Literature 1

    • Title

    • Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.

    • Reference

    • J Bacteriol. 2010 Feb;192(4):1131-42.

    • Author

    • Daly KM, Upton M, Sandiford SK, Draper LA, Wescombe PA, Jack RW, O'Connor PM, Rossney A, G?tz F, Hill C, Cotter PD, Ross RP, Tagg JR.