• • DRAMP ID

  • DRAMP18325

• • Peptide Name

  • delta-lysin I (Bacteriocin)

• • Source

  • Staphylococcus warneri RK

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • MAADIISTIGDLVKLIINTVKKFQK

• • Sequence Length

  • 25

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.18339450]Gram-positive bacteria: Bacillus megaterium F04(+), Bacillus subtilis(–), Enterococcus faecalis V583(–), Listeria monocytogenes EGDe(–), Micrococcus luteus(–), Pediococcus acidilactici 583(–), Staphylococcus aureus 971(–), Staphylococcus chromogenes(–), Staphylococcus cohnii 898(–), Staphylococcus epidermidis 567(-), Staphylococcus haemolyticus 694(-), Staphylococcus hominis 373(-), Staphylococcus lentus 982(-), Staphylococcus lugdunensis 967(-), Staphylococcus saprophyticus 715(-), Staphylococcus warneri 447(-), Staphylococcus warneri RK(-);
    • Gram-negative bacteria:  Enterobacter cloacae D03(-), Escherichia coli MG1655(-), Hafnia alvei(-), Klebsiella pneumoniae 0502083(-), Legionella bozemanii ATCC 33217(+),  Legionella dumofii ATCC 33279(+), Legionella feeleii ATCC 35072(+), Legionella like bacteria (LLAP10)(+), Legionella longbeachae ATCC 33484(+), Legionella micdadei ATCC 33218(+), Legionella oakridgensis ATCC 33761(+), Legionella pneumophila Corby (sg1)(+), Legionella pneumophila Lens (sg1)(+), Legionella pneumophila Paris (sg1)(+), Legionella pneumophila ATCC 33155 (sg3)(+), Legionella pneumophila ATCC 33216 (sg5)(+), Legionella pneumophila ATCC 33215 (sg6)(+), Proteus mirabilis ATCC 35659(-), Pseudomonas aeruginosa DSMZ1128(-), Pseudomonas aeruginosa 910704(-), Salmonella typhimurium(-)

• • Hemolytic Activity

  • • [Ref.18339450]10% hemolytic activity at 1.56 μM, 40% hemolytic activity at 6.25 μM, 62% hemolytic activity at 25 μM, 80% hemolytic activity at 50 μM against human erythrocytes

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP18325.

DRAMP18325

• • Warnericin RK and delta-lysin I displayed the same antibacterial spectrum, which is almost restricted to the Legionella genus. Also, both peptides have a hemolytic activity.

• ·Literature 1

• • Title

  • Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri.

• • Pubmed ID

  • 18339450

• • Reference

  • Peptides. 2008 Jun;29(6):978-84.

• • Author

  • Verdon J, Berjeaud JM, Lacombe C, H