General Information

    • DRAMP ID

    • DRAMP18331

    • Peptide Name

    • Antibacterial peptide A-M49 (Bacteriocin)

    • Source

    • Streptococcus pyogenes serotype M49

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • scnA' AND scnA''

    • Sequence

    • GKNGVFKTISHECHLNTWAFLATCCS

    • Sequence Length

    • 26

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • There are one 2,3-didehydrobutyrine at T23, two Beta-methyllanthionines (T8-C13; T17-C25) and one Lanthionine (S10-C24).

    • Helical Wheel Diagram

    • DRAMP18331 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18331.

Physicochemical Information

    • Formula

    • C126H191N35O36S3

    • Absent Amino Acids

    • DMPQRY

    • Common Amino Acids

    • CT

    • Mass

    • 2868.3

    • PI

    • 7.97

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • -1859

    • Hydrophobicity

    • 0.112

    • Aliphatic Index

    • 63.85

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 225

    • Polar Residues

    • 12

DRAMP18331

DRAMP18331 chydropathy plot

Comments Information

    • There are two genes coding for lantibiotic streptococcin A-M49, their coding sequences only differ in the propeptide region.

Literature Information

  • ·Literature 1

    • Title

    • Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.

    • Reference

    • Appl Environ Microbiol. 1994 Nov;60(11):4207-9.

    • Author

    • Hynes WL, Friend VL, Ferretti JJ.