General Information
-
DRAMP ID
- DRAMP18332
-
Peptide Name
- BHT-Aa(Bacteriocin)
-
Source
- Streptococcus rattus BHT
-
Family
- Belongs to the lantibiotics family (Class I bacteriocin)
-
Gene
- bht-a
-
Sequence
- GTTVVNSTFSIVLGNKGYICTVTVECMRNCQ
-
Sequence Length
- 31
-
UniProt Entry
- No entry found
-
Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
- Gram-positive
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- tryptophan rich
-
Structure Description
- A variant of Smb, as evidenced by the fact that the two operons share 95% identity.
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP18332.
Physicochemical Information
-
Formula
- C141H233N39O46S4
Absent Amino Acids
- ADHPW
Common Amino Acids
- TV
Mass
- 3338.87
PI
- 7.95
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- -2558
Hydrophobicity
- 0.403
Aliphatic Index
- 84.52
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1615
Absorbance 280nm
- 53.83
Polar Residues
- 17
DRAMP18332
Comments Information
The amino acid sequence of another chain (BhtA2) is STPACAIGVVGITVAVTGISTACTSRCINK, which is identical to SmbA.
Literature Information
- ·Literature 1
-
Title
- Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin.
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Pubmed ID
- 16194596
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Reference
- FEMS Microbiol Lett. 2005 Nov 15;252(2):235-41.
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Author
- Hyink O, Balakrishnan M, Tagg JR.
- ·Literature 2
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Title
- Two-peptide lantibiotics: a medical perspective.
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Pubmed ID
- 18220976
-
Reference
- Mini Rev Med Chem. 2007 Dec;7(12):1236-47.
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Author
- Lawton EM, Ross RP, Hill C, Cotter PD.