General Information

    • DRAMP ID

    • DRAMP18335

    • Peptide Name

    • Salivaricin G32(Bacteriocin)

    • Source

    • Streptococcus salivarius strain G32

    • Family

    • Belongs to the lantibiotics family (Class I bacteriocin)

    • Gene

    • slnA

    • Sequence

    • GNGVFKTISHECHLNTWAFLATCCS

    • Sequence Length

    • 25

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • Gram-positive

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • The first modified amino acid was found to be a dehydrobutyrine (Dhb) at position 8 that could form a beta-methyl-lanthionine bond with Cys13. A second beta-methyl-lanthionine formation between Dhb and Cys was found at positions 10 and 32, respectively. A disulfide bridge was between the two Cys residues at positions 21 and 29. The data is in accordance with the sequence analysis of bovicin HJ50 and thermophilin 1277.

    • Helical Wheel Diagram

    • DRAMP18335 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18335.

Physicochemical Information

    • Formula

    • C120H179N33O35S3

    • Absent Amino Acids

    • DMPQRY

    • Common Amino Acids

    • CT

    • Mass

    • 2740.12

    • PI

    • 6.89

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • -1304

    • Hydrophobicity

    • 0.272

    • Aliphatic Index

    • 66.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 234.38

    • Polar Residues

    • 12

DRAMP18335

DRAMP18335 chydropathy plot

Comments Information

    • The inhibitory peptide differs from the Streptococcus pyogenes-produced SA-FF22 in the absence of lysine in position 2.

Literature Information

  • ·Literature 1

    • Title

    • Salivaricin G32, a Homolog of the Prototype Streptococcus pyogenes Nisin-Like Lantibiotic SA-FF22, Produced by the Commensal Species Streptococcus salivarius.

    • Reference

    • Int J Microbiol. 2012;2012:738503.

    • Author

    • Wescombe PA, Dyet KH, Dierksen KP, Power DA, Jack RW, Burton JP, Inglis MA, Wescombe AL, Tagg JR.
  • ·Literature 2

    • Title

    • Macedovicin, the second food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198.

    • Reference

    • Food Microbiol. 2013 Feb;33(1):124-30.

    • Author

    • Georgalaki M, Papadimitriou K, Anastasiou R, Pot B, Van Driessche G, Devreese B, Tsakalidou E.