General Information

    • DRAMP ID

    • DRAMP18341

    • Peptide Name

    • Daptomycin(Bacteriocin)

    • Source

    • Streptomyces roseosporus NRRL11379

    • Family

    • Belongs to the lipopeptides family

    • Gene

    • Not found

    • Sequence

    • WNDTGKDADGSEY

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • the sequence is a close mimic of the natural counterpart. The natural form is cyclic due to the ester bond between the hydroxyl of T4 and the carboxyl of kynurenine-13 (represented by Y here). The N-terminus is lipidated with n-decanoyl fatty acid chain. Other nonstandard amino acids include ornithine-6 (represented with K), (2S,3R)-3-methyl-glutamic acid-12 (represented with E), and three D-amino acids at positions N2, A8, and S11.

    • Helical Wheel Diagram

    • DRAMP18341 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18341.

Physicochemical Information

    • Formula

    • C61H84N16O26

    • Absent Amino Acids

    • CFHILMPQRV

    • Common Amino Acids

    • D

    • Mass

    • 1457.43

    • PI

    • 3.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 2

    • Net Charge

    • -3

    • Boman Index

    • -4525

    • Hydrophobicity

    • -1.854

    • Aliphatic Index

    • 7.69

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 582.5

    • Polar Residues

    • 6

DRAMP18341

Comments Information

    • In 2003, FDA approved daptomycin as a new peptide antibiotic.

Literature Information

  • ·Literature 1

    • Title

    • In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibiotic.

    • Reference

    • Antimicrob Agents Chemother. 1986 Oct;30(4):532-5.

    • Author

    • Eliopoulos GM, Willey S, Reiszner E, Spitzer PG, Caputo G, Moellering RC Jr.