General Information

    • DRAMP ID

    • DRAMP18343

    • Peptide Name

    • BI-32169(Bacteriocin)

    • Source

    • Streptomyces sp. (DSM 14996)

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • GLPWGCPSDIPGWNTPWAC

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antidiabetic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • BI-32169 consists exclusively of protein amino acids and is cyclized from the side chain of Asp9 to the N-terminus of Gly1. One disulfide bond between Cys6 and Cys19 forms a bicyclic structure.

    • Helical Wheel Diagram

    • DRAMP18343 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18343.

Physicochemical Information

    • Formula

    • C95H129N23O25S2

    • Absent Amino Acids

    • EFHKMQRVY

    • Common Amino Acids

    • P

    • Mass

    • 2057.33

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • -1

    • Boman Index

    • 269

    • Hydrophobicity

    • -0.195

    • Aliphatic Index

    • 46.32

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 16625

    • Absorbance 280nm

    • 923.61

    • Polar Residues

    • 8

DRAMP18343

DRAMP18343 chydropathy plot

Comments Information

    • BI-32169 and its methyl ester derivative (2) showed potent inhibitory activity against the human glucagon receptor (IC50 440 and 320 nM, respectively) in a functional cell-based assay.

Literature Information

  • ·Literature 1

    • Title

    • BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp.

    • Reference

    • J Nat Prod. 2004 Sep;67(9):1528-31.

    • Author

    • Potterat O, Wagner K, Gemmecker G, Mack J, Puder C, Vettermann R, Streicher R.