General Information

    • DRAMP ID

    • DRAMP18344

    • Peptide Name

    • Tricyclic peptide RP 71955 (Bacteriocin)

    • Source

    • Streptomyces sp. (strain SP9440)

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • CLGIGSCNNFAGCGYAVVCFW

    • Sequence Length

    • 21

    • Protein Existence

Activity Information

    • Biological Activity

    • Antiviral, Anti-HIV, Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta strand

    • Structure Description

    • An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. In contrast. Class 2 lassos do not have disulfide bonds.

    • Helical Wheel Diagram

    • DRAMP18344 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP18344.

Physicochemical Information

    • Formula

    • C97H138N24O26S4

    • Absent Amino Acids

    • DEHKMPQRT

    • Common Amino Acids

    • CG

    • Mass

    • 2184.55

    • PI

    • 5.5

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • 0

    • Boman Index

    • 2189

    • Hydrophobicity

    • 1.157

    • Aliphatic Index

    • 74.29

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 362

    • Polar Residues

    • 12

DRAMP18344

DRAMP18344 chydropathy plot

Comments Information

    • Caution

    • The isopeptide linked residue 9 is shown as Asn rather than Asp as mentioned in PubMed

Literature Information

  • ·Literature 1

    • Title

    • Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.

    • Reference

    • J Antibiot (Tokyo). 1993 Nov;46(11):1756-7.

    • Author

    • Helynck G, Dubertret C, Mayaux JF, Leboul J.