• DRAMP ID

    • DRAMP18345
    • Peptide Name

    • Tricyclic peptide RP 71955 (Bacteriocin)
    • Source

    • Streptomyces sp. (strain SP9440)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • CLGIGSCNNFAGCGYAVVCFW
    • Sequence Length

    • 21
    • Protein Existence

    • Biological Activity

    • Antiviral, Anti-HIV, Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Beta strand
    • Structure Description

    • An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19.
    • Helical Wheel Diagram

    • DRAMP18345 helical wheel diagram
    • Predicted Structure

    • There is no predicted structure for DRAMP18345.
    • Formula

    • C97H138N24O26S4
    • Absent Amino Acids

    • DEHKMPQRT
    • Common Amino Acids

    • CG
    • Mass

    • 2184.55
    • PI

    • 5.5
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • 0
    • Boman Index

    • 2189
    • Hydrophobicity

    • 1.157
    • Aliphatic Index

    • 74.29
    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 7240
    • Absorbance 280nm

    • 362
    • Polar Residues

    • 12

DRAMP18345

DRAMP18345 chydropathy plot
    • Caution

    • The isopeptide linked residue 9 is shown as Asn rather than Asp as mentioned in PubMed
  • ·Literature 1
    • Title

    • Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.
    • Reference

    • J Antibiot (Tokyo). 1993 Nov;46(11):1756-7.
    • Author

    • Helynck G, Dubertret C, Mayaux JF, Leboul J.