General Information

    • DRAMP ID

    • DRAMP18346

    • Peptide Name

    • Legonaridin(Bacteriocin)

    • Source

    • Streptomyces sp. CT34

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • legA

    • Sequence

    • ITPLATLATPEATPVGFAATSATAAAVNMITHDVTRH

    • Sequence Length

    • 37

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Unknown

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Despite the same chemical features as those observed in cypemycin and grisemycin, legonaridin 1 has a structurally different C-terminus with a free carboxylic acid.

    • Helical Wheel Diagram

    • DRAMP18346 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18346.

Physicochemical Information

    • Formula

    • C163H265N45O52S

    • Absent Amino Acids

    • CKQWY

    • Common Amino Acids

    • A

    • Mass

    • 3719.23

    • PI

    • 5.99

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +1

    • Boman Index

    • -1601

    • Hydrophobicity

    • 0.462

    • Aliphatic Index

    • 90

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 11

DRAMP18346

DRAMP18346 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate.

    • Reference

    • Org Biomol Chem. 2015 Oct 7;13(37):9585-92.

    • Author

    • Rateb ME, Zhai Y, Ehrner E, Rath CM, Wang X, Tabudravu J, Ebel R, Bibb M, Kyeremeh K, Dorrestein PC, Hong K, Jaspars M, Deng H.