General Information

    • DRAMP ID

    • DRAMP18347

    • Peptide Name

    • Siamycin(Bacteriocin)

    • Source

    • Streptomyces sp. No. 73264

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • CLGVGSCNDFAGCGYAIVCFW

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antiviral, Anti-HIV, Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • It differs from siamycin I only at position 17 (V to I).

    • Helical Wheel Diagram

    • DRAMP18347 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18347.

Physicochemical Information

    • Formula

    • C97H137N23O27S4

    • Absent Amino Acids

    • EHKMPQRT

    • Common Amino Acids

    • CG

    • Mass

    • 2185.53

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • -1

    • Boman Index

    • 1981

    • Hydrophobicity

    • 1.157

    • Aliphatic Index

    • 74.29

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 362

    • Polar Residues

    • 11

DRAMP18347

DRAMP18347 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • NP-06: a novel anti-human immunodeficiency virus polypeptide produced by a Streptomyces species.

    • Reference

    • Antimicrob Agents Chemother. 1995 Oct;39(10):2345-7.

    • Author

    • Chokekijchai S, Kojima E, Anderson S, Nomizu M, Tanaka M, Machida M, Date T, Toyota K, Ishida S, Watanabe K, et al.