General Information

    • DRAMP ID

    • DRAMP18349

    • Peptide Name

    • Siamycin I (Bacteriocin)

    • Source

    • Streptomyces strain AA6532

    • Family

    • Belongs to the class I bacteriocin

    • Gene

    • Not found

    • Sequence

    • CLGVGSCNDFAGCGYAVVCFW

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antiviral, Anti-HIV, Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta strand

    • Structure Description

    • It differs from Siamycin I only by one amino acid. Siamycin I has a valine residue at position 4. In both peptides, disulfide bonds link Cys1 with Cys13 and Cys7 with Cys19, and the side chain of Asp9 forms an amide bond with the N-terminus (XXJ). The original has been replaced since antimicrobial assays revealed no activity.

    • Helical Wheel Diagram

    • DRAMP18349 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18349.

Physicochemical Information

    • Formula

    • C96H135N23O27S4

    • Absent Amino Acids

    • EHIKMPQRT

    • Common Amino Acids

    • CG

    • Mass

    • 2171.51

    • PI

    • 3.8

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • -1

    • Boman Index

    • 1893

    • Hydrophobicity

    • 1.143

    • Aliphatic Index

    • 69.52

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 362

    • Polar Residues

    • 11

DRAMP18349

DRAMP18349 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I.

    • Reference

    • J Antibiot (Tokyo). 1995 Dec;48(12):1515-7.

    • Author

    • Detlefsen DJ, Hill SE, Volk KJ, Klohr SE, Tsunakawa M, Furumai T, Lin PF, Nishio M, Kawano K, Oki T, et al.