General Information
-
DRAMP ID
- DRAMP18357
-
Peptide Name
- Warnerin (bacteriocin)
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Source
- Staphylococcus warneri KL-1
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Family
- Belongs to the lantibiotic family.
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Gene
- Not found
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Sequence
- ASVVKTTIKASKKLCKGATLTCGCNITGKK
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Sequence Length
- 30
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UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- Active against S. epidermis (MIC <1 ug/ml), S. epidermis ATCC 700566 (MIC 8 ug/ml), S. epidermis ATCC 700567 (MIC 8 ug/ml), Staphylococcus sp. ATCC 700575 (MIC 32 ug/ml), S. aureus (VISA) CCUG 45315 (MIC 1.5 ug/ml), K. pneumoniae ATCC 700603 (MIC 96 ug/ml), E. faecium ATCC 51559 (MIC 64 ug/ml), and E. faecium (VRE) ATCC 700221 (MIC 32 ug/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18357.
Physicochemical Information
-
Formula
- C130H236N38O38S3
Absent Amino Acids
- DEFHMPQRWY
Common Amino Acids
- K
Mass
- 3053.73
PI
- 9.95
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +7
-
Boman Index
- -2529
Hydrophobicity
- 0.026
Aliphatic Index
- 78.71
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 4.17
Polar Residues
- 14
DRAMP18357
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Identification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri.
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Pubmed ID
- 19361283
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Reference
- Biol Chem. 2009 May-Jun;390(5-6):437-44
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Author
- Petersen J, Boysen A, Fogh L, Tabermann K, Kofoed T, King A, Schrotz-King P, Hansen MC