General Information

    • DRAMP ID

    • DRAMP18360

    • Peptide Name

    • Paenicidin B (bacteriocin)

    • Source

    • Paenibacillus terrae; old: Bacillus circulans NRRL B-30644

    • Family

    • Belongs to the lantibiotic family.

    • Gene

    • Not found

    • Sequence

    • VLSIVACSSGCGSGKTAASCVATCGNKCFTNVGSLC

    • Sequence Length

    • 36

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against B. subtilis JH642 (MIC 50 uM), L. lactis subsp. cremoris HP (12.5 uM), L. monocytogenes ATCC 15313 (100 uM), and S. aureus ATCC 25923 (MIC 100 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18360 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18360.

Physicochemical Information

    • Formula

    • C137H232N40O48S6

    • Absent Amino Acids

    • DEHMPQRWY

    • Common Amino Acids

    • CS

    • Mass

    • 3399.95

    • PI

    • 8.34

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • 103

    • Hydrophobicity

    • 0.839

    • Aliphatic Index

    • 75.83

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 10.71

    • Polar Residues

    • 22

DRAMP18360

DRAMP18360 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Biochemical, structural, and genetic characterization of tridecaptin A?, an antagonist of Campylobacter jejuni.

    • Reference

    • Chembiochem. 2014 Jan 24;15(2):243-9.

    • Author

    • Lohans CT1, van Belkum MJ, Cochrane SA, Huang Z, Sit CS, McMullen LM, Vederas JC.