General Information

    • DRAMP ID

    • DRAMP18363

    • Peptide Name

    • Sviceucin (bacteriocin)

    • Source

    • Streptomyces sviceus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CVWGGDCTDFLGCGTAWICV

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: B. megaterium, L. bulgaricus 340, S. aureus subsp. aureus ATCC 6538, L. sakei subsp. sakei DSM 20017.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipid II

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18363 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18363.

Physicochemical Information

    • Formula

    • C92H130N22O26S4

    • Absent Amino Acids

    • EHKMNPQRSY

    • Common Amino Acids

    • CG

    • Mass

    • 2106.43

    • PI

    • 3.56

    • Basic Residues

    • 0

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • -2

    • Boman Index

    • 1367

    • Hydrophobicity

    • 0.929

    • Aliphatic Index

    • 69.52

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11250

    • Absorbance 280nm

    • 562.5

    • Polar Residues

    • 10

DRAMP18363

DRAMP18363 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Characterization of Sviceucin from Streptomyces Provides Insight into Enzyme Exchangeability and Disulfide Bond Formation in Lasso Peptides

    • Reference

    • ACS Chem Biol. 2015 Nov 20;10(11):2641-9.

    • Author

    • Li Y, Ducasse R, Zirah S, Blond A, Goulard C, Lescop E, Giraud C, Hartke A, Guittet E, Pernodet JL, Rebuffat S.