General Information

    • DRAMP ID

    • DRAMP18364

    • Peptide Name

    • Thuricin 4A-4 (bacteriocin)

    • Source

    • Bacillus thuringiensis serovar thuringiensis T01001

    • Family

    • Belongs to the lantibiotic family.

    • Gene

    • Not found

    • Sequence

    • WTTIVKVSKAVCKTGTCICTTSCSNCK

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against B. cereus, B. firmus, B. thuringiensis, B. subtilis, B. pumilus, E. faecalis, M. Paenibacillus, S. aureus, and S. sciuri.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18364 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18364.

Physicochemical Information

    • Formula

    • C119H205N33O38S5

    • Absent Amino Acids

    • DEFHLMPQRY

    • Common Amino Acids

    • T

    • Mass

    • 2866.44

    • PI

    • 9.04

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -2102

    • Hydrophobicity

    • 0.33

    • Aliphatic Index

    • 64.81

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5750

    • Absorbance 280nm

    • 221.15

    • Polar Residues

    • 16

DRAMP18364

DRAMP18364 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • The Bacillus cereus group is an excellent reservoir of novel lanthipeptides.

    • Reference

    • Appl Environ Microbiol. 2015 Mar;81(5):1765-74.

    • Author