General Information

    • DRAMP ID

    • DRAMP18367

    • Peptide Name

    • Chaxapeptin (a class 2 lasso peptide; class 1 microcin, bacteriocins)

    • Source

    • Streptomyces leeuwenhoekii Strain C58

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFGSKPLDSFGLNFF

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-cancer

    • Target Organism

      • Gram-positive bacteria: S. aureus and B. subtilis (MIC 30-35 ug/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18367 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18367.

Physicochemical Information

    • Formula

    • C79H107N17O20

    • Absent Amino Acids

    • ACEHIMQRTVWY

    • Common Amino Acids

    • F

    • Mass

    • 1632.84

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • 0

    • Boman Index

    • -313

    • Hydrophobicity

    • 0.219

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18367

Comments Information

    • Fuction

    • No activity against the Gram-negative bacteria. It showed dose dependent inhibition of A549 cancer cells.

Literature Information

  • ·Literature 1

    • Title

    • Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

    • Reference

    • J Org Chem. 2015 Oct 16;80(20):10252-60.

    • Author

    • Elsayed SS, Trusch F, Deng H, Raab A, Prokes I, Busarakam K, Asenjo JA, Andrews BA, van West P, Bull AT, Goodfellow M, Yi Y, Ebel R, Jaspars M, Rateb ME