General Information

    • DRAMP ID

    • DRAMP18385

    • Peptide Name

    • cOT2 (reptiles; animals)

    • Source

    • Siamese crocodile, Crocodylus siamensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KKSCHTGLKKSAGWVIPIGTLVKNGIIVR

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against E. coli ATCC 25922 (MIC 32 uM), V. cholerae (MIC 8 uM), Gram+ B. megaterium (MIC 8 uM) and B. pumilus TISTR 905 (MIC 16 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18385 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18385.

Physicochemical Information

    • Formula

    • C141H241N41O34S

    • Absent Amino Acids

    • DEFMQY

    • Common Amino Acids

    • K

    • Mass

    • 3104.79

    • PI

    • 10.6

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +7

    • Boman Index

    • -1509

    • Hydrophobicity

    • 0.157

    • Aliphatic Index

    • 110.33

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 189.66

    • Polar Residues

    • 10

DRAMP18385

DRAMP18385 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial effects of novel peptides cOT2 and sOT3 derived from Crocodylus siamensis and Pelodiscus sinensis ovotransferrins

    • Reference

    • Biochim Biophys Acta Biomembr. 2017 May;1859(5):860-869.

    • Author

    • Prajanban BO, Jangpromma N, Araki T, Klaynongsruang S