General Information
-
DRAMP ID
- DRAMP18387
-
Peptide Name
- VK14 (histone derived;reptiles; animals)
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Source
- blood plasma, Komodo dragon, Varanus komodoensis
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KAAAAKKSPKKPKKPAAAKK
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- Active against P. eruginosa ATCC9027 (EC50 0.6 uM) and S. aureus ATCC 25923 (EC50 1.2 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18387.
Physicochemical Information
-
Formula
- C93H171N29O22
Absent Amino Acids
- CDEFGHILMNQRTVWY
Common Amino Acids
- K
Mass
- 2047.56
PI
- 10.9
Basic Residues
- 9
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +9
-
Boman Index
- -4068
Hydrophobicity
- -1.405
Aliphatic Index
- 35
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP18387
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry
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Pubmed ID
- 28164707
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Reference
- J Proteome Res. 2017 Apr 7;16(4):1470-1482.
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Author
- Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML