General Information

    • DRAMP ID

    • DRAMP18389

    • Peptide Name

    • VK12 (histone derived; animals)

    • Source

    • blood plasma, Komodo dragon, Varanus komodoensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AKKPVAKKAAGGVKKPKK

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against P. eruginosa ATCC9027 (EC50 0.7 uM) and S. aureus ATCC 25923 (EC50 0.8 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18389 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18389.

Physicochemical Information

    • Formula

    • C84H156N26O19

    • Absent Amino Acids

    • CDEFHILMNQRSTWY

    • Common Amino Acids

    • K

    • Mass

    • 1834.33

    • PI

    • 10.85

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +8

    • Boman Index

    • -2720

    • Hydrophobicity

    • -1.089

    • Aliphatic Index

    • 54.44

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP18389

DRAMP18389 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo-Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry

    • Reference

    • J Proteome Res. 2017 Apr 7;16(4):1470-1482.

    • Author

    • Bishop BM, Juba ML, Russo PS, Devine M, Barksdale SM, Scott S, Settlage R, Michalak P, Gupta K, Vliet K, Schnur JM, van Hoek ML