General Information
-
DRAMP ID
- DRAMP18395
-
Peptide Name
- moroPC-NH2 (moronecidin-like peptide; fish, animals)
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Source
- Parachaenichthys charcoti
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Family
- Not found
-
Gene
- Not found
-
Sequence
- FFGHLFRGIINVGKHIHGLLSG
-
Sequence Length
- 22
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UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- Active against Gram- E. cloacae ATCC 13047 (MIC 25 uM), S. sonnei (ATCC 29930) (MIC 5 uM), Psychrobacter sp. (PAMC 25501) (MIC 2.5 uM), E. coli DH5alpha (MIC 5 uM), Gram+ E. faecalis (ATCC 29212) (MIC 25 uM), S. pyogenes (ATCC 19615) (MIC 2.5 uM), S. aureus (ATCC 33591), L. monocytogenes (ATCC 15313) (MIC 5 uM), and yeast C. tropicalis (ATCC 20115) (MIC 5 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18395.
Physicochemical Information
-
Formula
- C115H175N33O25
Absent Amino Acids
- ACDEMPQTWY
Common Amino Acids
- G
Mass
- 2419.86
PI
- 11
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +5
-
Boman Index
- 271
Hydrophobicity
- 0.6
Aliphatic Index
- 119.55
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 7
DRAMP18395
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Characterization of Two Antimicrobial Peptides from Antarctic Fishes (Notothenia coriiceps and Parachaenichthys charcoti)
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Pubmed ID
- 28122029
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Reference
- PLoS One. 2017 Jan 25;12(1):e0170821.
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Author
- Shin SC, Ahn IH, Ahn DH, Lee YM, Lee J, Lee JH, Kim HW, Park H