General Information

    • DRAMP ID

    • DRAMP18405

    • Peptide Name

    • PDC213 (beta-casein 213-224, human)

    • Source

    • milk, Homo sapiens

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VTQPLAPVHNPISV

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against S. aureus and Y. enterocolitica (80% inhibition at 15 ug/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18405 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18405.

Physicochemical Information

    • Formula

    • C67H110N18O19

    • Absent Amino Acids

    • CDEFGKMRWY

    • Common Amino Acids

    • PV

    • Mass

    • 1471.72

    • PI

    • 6.71

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • 96

    • Hydrophobicity

    • 0.443

    • Aliphatic Index

    • 125

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP18405

Comments Information

    • It is a endogenous peptide with higher levels in preterm milk.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity and mechanism of PDC213, an endogenous peptide from human milk.

    • Reference

    • Biochem Biophys Res Commun. 2017 Feb 26;484(1):132-137.

    • Author

    • Sun Y, Zhou Y, Liu X, Zhang F, Yan L, Chen L, Wang X, Ruan H, Ji C, Cui X, Wang J.