General Information

    • DRAMP ID

    • DRAMP18408

    • Peptide Name

    • Dm-AMP2 (Dahlia defensin, plants)

    • Source

    • seeds, Dahlia merckii

    • Family

    • Belongs to the defensin family.

    • Gene

    • Not found

    • Sequence

    • EVCEKASKTWSGNCGNTGHC

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • Active against fungi B. cinerea (IC50 10 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 3 ug/ml), L. maculans (IC50 1.0 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 2 ug/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18408 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18408.

Physicochemical Information

    • Formula

    • C84H129N27O30S3

    • Absent Amino Acids

    • DFILMPQRY

    • Common Amino Acids

    • CG

    • Mass

    • 2111.31

    • PI

    • 6.82

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +1

    • Boman Index

    • -3976

    • Hydrophobicity

    • -0.791

    • Aliphatic Index

    • 18.57

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 281.25

    • Polar Residues

    • 12

DRAMP18408

DRAMP18408 chydropathy plot

Comments Information

    • Fuction

    • The sequence is not yet complete.In medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 10 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 3 ug/ml), L. maculans (IC50 1.0 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 2 ug/ml).

Literature Information

  • ·Literature 1

    • Title

    • Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae

    • Reference

    • FEBS Lett. 1995 Jul 17;368(2):257-62

    • Author

    • Attenborough S, Rees SB, Broekaert WF.