General Information

    • DRAMP ID

    • DRAMP18409

    • Peptide Name

    • Mastoparan V1 (MP-V1, insects, arthropods, invertebrates, animals)

    • Source

    • Venom; Social Wasp, Vespula vulgaris

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INWKKIKSIIKAAMN

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Active against S. mutans, S. enterica, and S. aureus (MIC 50 uM), and C. albicans, C. grabrata (MIC 50 uM), and C. neoformans (MIC 0.5 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18409 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18409.

Physicochemical Information

    • Formula

    • C81H140N22O19S

    • Absent Amino Acids

    • CDEFGHLPQRTVY

    • Common Amino Acids

    • IK

    • Mass

    • 1758.2

    • PI

    • 10.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -1090

    • Hydrophobicity

    • -0.053

    • Aliphatic Index

    • 117.33

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 3

DRAMP18409

Comments Information

    • Weak hemolysis 6.6% at 50 uM (20% at 100 uM).

Literature Information

  • ·Literature 1

    • Title

    • MP-V1 from the Venom of Social Wasp Vespula vulgaris Is a de Novo Type of Mastoparan that Displays Superior Antimicrobial Activities.

    • Reference

    • Molecules. 2016 Apr 19;21(4):512.

    • Author

    • Kim Y, Son M, Noh EY, Kim S, Kim C, Yeo JH, Park C, Lee KW, Bang WY.