General Information

    • DRAMP ID

    • DRAMP18411

    • Peptide Name

    • Thaulin-1 (frog, amphibians, animals; Other sequences reported: Thaulin-2, Thaulin-3, Thaulin-4)

    • Source

    • skin, a Patagonian frog, Pleurodema thaul, South America

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • NGNLLGGLLRPVLGVVKGLTGGLGKK

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against E. coli ATCC 25922 (MIC 62.5 ug/ml), K. pneumoniae (MIC 125 ug/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18411 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18411.

Physicochemical Information

    • Formula

    • C114H202N34O29

    • Absent Amino Acids

    • ACDEFHIMQSWY

    • Common Amino Acids

    • G

    • Mass

    • 2531.08

    • PI

    • 11.26

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +4

    • Boman Index

    • 666

    • Hydrophobicity

    • 0.389

    • Aliphatic Index

    • 133.33

    • Half Life

      • Mammalian:1.4 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 11

DRAMP18411

DRAMP18411 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli.

    • Reference

    • Gene. 2017 Mar 20;605:70-80

    • Author

    • Marani MM, Perez LO, de Araujo AR, Pl