General Information

    • DRAMP ID

    • DRAMP18412

    • Peptide Name

    • Longipin (arachnids, Chelicerata, arthropods, invertebrates, animals)

    • Source

    • hemolymph, Acutisoma longipes

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SGYLPGKEYVYKYKGKVF

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • Active against M. luteus A270, Gram- P. aeruginosa ATCC27853, S. marcescens ATCC4112 (MIC 60-120 uM), fungi C. albicans MDM8 (MIC 15-30 uM), C. albicans IOC4558 (7.5-15 uM), C. guilliermondii and C. tropicalis (MIC 3.8-7.5 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18412 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18412.

Physicochemical Information

    • Formula

    • C104H152N22O26

    • Absent Amino Acids

    • ACDHIMNQRTW

    • Common Amino Acids

    • KY

    • Mass

    • 2126.48

    • PI

    • 9.52

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -1417

    • Hydrophobicity

    • -0.717

    • Aliphatic Index

    • 53.89

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5960

    • Absorbance 280nm

    • 350.59

    • Polar Residues

    • 8

DRAMP18412

DRAMP18412 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Longipin: An Amyloid Antimicrobial Peptide from the Harvestman Acutisoma longipes (Arachnida: Opiliones) with Preferential Affinity for Anionic Vesicles

    • Reference

    • PLoS One. 2016 Dec 20;11(12):e0167953.

    • Author

    • Sayegh RS, Batista IF, Melo RL, Riske KA, Daffre S, Montich G, da Silva Junior PI