General Information

    • DRAMP ID

    • DRAMP18413

    • Peptide Name

    • Phylloseptin-PBa (frog, amphibians, animals)

    • Source

    • the Peruvian Purple-Sided Leaf Frog, Phyllomedusa baltea , South America

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFSMIPKIAGGIASLVKNLG

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Active against S. aureus (MIC 8 ug/ml), E. coli (MIC 128 ug/ml) and C. albicans (MIC 8 ug/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18413 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18413.

Physicochemical Information

    • Formula

    • C97H159N23O24S

    • Absent Amino Acids

    • CDEHQRTWY

    • Common Amino Acids

    • GI

    • Mass

    • 2063.53

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +2

    • Boman Index

    • 1885

    • Hydrophobicity

    • 1.035

    • Aliphatic Index

    • 122

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP18413

DRAMP18413 chydropathy plot

Comments Information

    • Fuction

    • It exhibited anti-proliferative activity against the human cancer cell lines, H460, PC3 and U251MG, but was less active against a normal human cell line (HMEC).

Literature Information

  • ·Literature 1

    • Title

    • Phylloseptin-PBa--A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity.

    • Reference

    • Toxins (Basel). 2015 Dec 1;7(12):5182-93

    • Author

    • Wan Y, Ma C, Zhou M, Xi X, Li L, Wu D, Wang L, Lin C, Lopez JC, Chen T, Shaw C