General Information

    • DRAMP ID

    • DRAMP18414

    • Peptide Name

    • NDBP-5.8 (scorpions, arachnids, Chelicerata, arthropods, invertebrates, animals)

    • Source

    • Opisthacanthus cayaporum

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GILGKIWEGVKSLI

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

    • Active against C. albicans SC5314 (MIC 100 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. parapsilosis ATCC 22019 (MIC 200 uM), C. neoformans H99 serotype A (MIC 100 uM), and C. neoformans B3501 serotype D (MIC 50 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18414 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18414.

Physicochemical Information

    • Formula

    • C72H119N17O17

    • Absent Amino Acids

    • ACDFHMNPQRTY

    • Common Amino Acids

    • GI

    • Mass

    • 1512.86

    • PI

    • 8.59

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 1248

    • Hydrophobicity

    • 0.74

    • Aliphatic Index

    • 149.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 392.86

    • Polar Residues

    • 4

DRAMP18414

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms

    • Reference

    • Front Microbiol. 2016 Nov 18;7:1844.

    • Author

    • Guilhelmelli F, Vilela N, Smidt KS, de Oliveira MA, da Cunha Morales ?lvares A, Rigonatto MC, da Silva Costa PH, Tavares AH, de Freitas SM, Nicola AM, Franco OL, Derengowski LD, Schwartz EF, Mortari MR, Bocca AL, Albuquerque P, Silva-Pereira I.