General Information
-
DRAMP ID
- DRAMP18415
-
Peptide Name
- Con10 (scorpions, arachnids, Chelicerata, arthropods, invertebrates, animals)
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Source
- Opisthacanthus cayaporum
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Family
- Not found
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Gene
- Not found
-
Sequence
- FWSFLVKAASKILPSLIGGGDDNKSSS
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Sequence Length
- 27
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UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antifungal
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Target Organism
- Active against C. albicans SC5314 (MIC 100 uM), C. tropicalis ATCC 750 (MIC 12.5 uM), C. parapsilosis ATCC 22019 (MIC 200 uM), C. glabrata ATCC 90030 (MIC 200 uM), C. neoformans H99 serotype A (MIC 50 uM), and C. neoformans B3501 serotype D (MIC 25 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18415.
Physicochemical Information
-
Formula
- C129H202N32O39
Absent Amino Acids
- CEHMQRTY
Common Amino Acids
- S
Mass
- 2825.21
PI
- 8.5
Basic Residues
- 3
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +1
-
Boman Index
- -1776
Hydrophobicity
- 0.115
Aliphatic Index
- 90.37
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 211.54
Polar Residues
- 10
DRAMP18415
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms
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Pubmed ID
- 27917162
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Reference
- Front Microbiol. 2016 Nov 18;7:1844
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Author
- Guilhelmelli F, Vilela N, Smidt KS, de Oliveira MA, da Cunha Morales ?lvares A, Rigonatto MC, da Silva Costa PH, Tavares AH, de Freitas SM, Nicola AM, Franco OL, Derengowski LD, Schwartz EF, Mortari MR, Bocca AL, Albuquerque P, Silva-Pereira I.