General Information
-
DRAMP ID
- DRAMP18423
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Peptide Name
- HEdefensin (arachnids, Chelicerata, arthropods, invertebrates, animals)
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Source
- hemolymph, Haemaphysalis longicornis
-
Family
- Not found
-
Gene
- Not found
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Sequence
- EEESEVAHLRVRRGFGCPLNQGACHRHCRSIRRRGGYCSGIIKQTCTCYRN
-
Sequence Length
- 51
-
UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18423.
Physicochemical Information
-
Formula
- C241H393N89O71S6
Absent Amino Acids
- DMW
Common Amino Acids
- R
Mass
- 5865.69
PI
- 9.43
Basic Residues
- 13
Acidic Residues
- 4
Hydrophobic Residues
- 10
Net Charge
- +9
-
Boman Index
- -16843
Hydrophobicity
- -0.814
Aliphatic Index
- 53.53
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 67.1
Polar Residues
- 21
DRAMP18423
Comments Information
Fuction
- The synthetic peptide showed virucidal activity against Langat virus (LGTV).
Literature Information
- ·Literature 1
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Title
- Characterization and antiviral activity of a newly identified defensin-like peptide, HEdefensin, in the hard tick Haemaphysalis longicornis
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Pubmed ID
- 27871830
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Reference
- Dev Comp Immunol. 2017 Mar;68:98-107
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Author
- Talactac MR, Yada Y, Yoshii K, Hernandez EP, Kusakisako K, Hiroki M, Galay RL, Fujisaki K, Mochizuki M, Tanaka T