General Information
-
DRAMP ID
- DRAMP18425
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Peptide Name
- Ocellatin-PT6 (frog, amphibians, animals)
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Source
- Skin Secretion, dorsal, Leptodactylus pustulatus
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Family
- Not found
-
Gene
- Not found
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Sequence
- GVFDIIKGAGKQLIAHAMEKIAEKVGLNKDGN
-
Sequence Length
- 32
-
UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Not found
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18425.
Physicochemical Information
-
Formula
- C149H248N42O43S
Absent Amino Acids
- CPRSTWY
Common Amino Acids
- GK
Mass
- 3365.94
PI
- 8.39
Basic Residues
- 6
Acidic Residues
- 4
Hydrophobic Residues
- 13
Net Charge
- +2
-
Boman Index
- -2742
Hydrophobicity
- -0.1
Aliphatic Index
- 100.61
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 7
DRAMP18425
Comments Information
Fuction
- It has leishmanicidal activity.
Literature Information
- ·Literature 1
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Title
- Characterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus.
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Pubmed ID
- 26107622
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Reference
- J Nat Prod. 2015 Jul 24;78(7):1495-504.
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Author
- Marani MM, Dourado FS, Quelemes PV, de Araujo AR, Perfeito ML, Barbosa EA, V
- ·Literature 2
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Title
- Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems.
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Pubmed ID
- 27463422
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Reference
- Biopolymers. 2016 Dec;105(12):873-86.
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Author