General Information

    • DRAMP ID

    • DRAMP18426

    • Peptide Name

    • Ocellatin-PT3 (frog, amphibians, animals)

    • Source

    • Skin Secretion, dorsal, Leptodactylus pustulatus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GVIDIIKGAGKDLIAHAIGKLAEKV

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antiparasitic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18426 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18426.

Physicochemical Information

    • Formula

    • C115H201N31O32

    • Absent Amino Acids

    • CFMNPQRSTWY

    • Common Amino Acids

    • I

    • Mass

    • 2530.05

    • PI

    • 8.44

    • Basic Residues

    • 5

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • 241

    • Hydrophobicity

    • 0.592

    • Aliphatic Index

    • 148.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP18426

DRAMP18426 chydropathy plot

Comments Information

    • Fuction

    • It has leishmanicidal activity.

Literature Information

  • ·Literature 1

    • Title

    • Characterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus.

    • Reference

    • J Nat Prod. 2015 Jul 24;78(7):1495-504.

    • Author

    • Marani MM, Dourado FS, Quelemes PV, de Araujo AR, Perfeito ML, Barbosa EA, V
  • ·Literature 2

    • Title

    • Ocellatin-PT antimicrobial peptides: High-resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems.

    • Reference

    • Biopolymers. 2016 Dec;105(12):873-86.

    • Author