General Information

    • DRAMP ID

    • DRAMP18429

    • Peptide Name

    • Saha-CATH5 (cathelicidins; mammals, animals)

    • Source

    • Tasmanian devil, Sarcophilus harrisii

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KRIGLIRLIGKILRGLRRLG

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Active against E. coli ATCC 25922, P. aeruginosa, E. faecalis, S. aureus ATCC 29213 (MRSA), S. pneumoniae ATCC 49619, S. pyogenes ATCC 19615, S. agalactiae ATCC 12386, S. agalactiae, S. anginosus, S. equi, and C. neoformans (MIC 32-64 ug/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18429 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18429.

Physicochemical Information

    • Formula

    • C104H195N37O20

    • Absent Amino Acids

    • ACDEFHMNPQSTVWY

    • Common Amino Acids

    • LR

    • Mass

    • 2301.94

    • PI

    • 12.6

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +7

    • Boman Index

    • -3766

    • Hydrophobicity

    • 0.243

    • Aliphatic Index

    • 167.14

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP18429

DRAMP18429 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Cathelicidins in the Tasmanian devil (Sarcophilus harrisii).

    • Reference

    • Sci Rep. 2016 Oct 11;6:35019

    • Author

    • Peel E, Cheng Y, Djordjevic JT, Fox S, Sorrell TC, Belov K