• DRAMP ID

    • DRAMP18435
    • Peptide Name

    • Labaditin (plants)
    • Source

    • Not found
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • VWTVWGTIAG
    • Sequence Length

    • 10
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • Active against S. mutans and S. aureus.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP18435 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP18435.
    • Formula

    • C53H76N12O13
    • Absent Amino Acids

    • CDEFHKLMNPQRSY
    • Common Amino Acids

    • GTVW
    • Mass

    • 1089.26
    • PI

    • 5.49
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Net Charge

    • 0
    • Boman Index

    • 1621
    • Hydrophobicity

    • 1.07
    • Aliphatic Index

    • 107
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 11000
    • Absorbance 280nm

    • 1222.22
    • Polar Residues

    • 4

DRAMP18435

    • The cyclic structure is critical for antimicrobial activity against S. aureus.

  • ·Literature 1
    • Title

    • Labaditin, a cyclic peptide with rich biotechnological potential: preliminary toxicological studies and structural changes in water and lipid membrane environment.
    • Reference

    • Amino Acids. 2011 Jan;40(1):135-44.
    • Author

    • Barbosa SC, Cilli EM, Dias LG, Stabeli RG, Ciancaglini P.
  • ·Literature 2
    • Title

    • The importance of cyclic structure for Labaditin on its antimicrobial activity against Staphylococcus aureus.
    • Reference

    • Colloids Surf B Biointerfaces. 2016 Dec 1;148:453-459.
    • Author

    • Barbosa SC, Nobre TM, Volpati D, Ciancaglini P, Cilli EM, Lorenz