General Information
-
DRAMP ID
- DRAMP18435
-
Peptide Name
- Labaditin (plants)
-
Source
- Not found
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- VWTVWGTIAG
-
Sequence Length
- 10
-
UniProt Entry
- No entry found
-
Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- Active against S. mutans and S. aureus.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18435.
Physicochemical Information
-
Formula
- C53H76N12O13
Absent Amino Acids
- CDEFHKLMNPQRSY
Common Amino Acids
- GTVW
Mass
- 1089.26
PI
- 5.49
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- 0
-
Boman Index
- 1621
Hydrophobicity
- 1.07
Aliphatic Index
- 107
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 1222.22
Polar Residues
- 4
DRAMP18435
Comments Information
The cyclic structure is critical for antimicrobial activity against S. aureus.
Literature Information
- ·Literature 1
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Title
- Labaditin, a cyclic peptide with rich biotechnological potential: preliminary toxicological studies and structural changes in water and lipid membrane environment.
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Pubmed ID
- 20563613
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Reference
- Amino Acids. 2011 Jan;40(1):135-44.
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Author
- Barbosa SC, Cilli EM, Dias LG, Stabeli RG, Ciancaglini P.
- ·Literature 2
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Title
- The importance of cyclic structure for Labaditin on its antimicrobial activity against Staphylococcus aureus.
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Pubmed ID
- 27665378
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Reference
- Colloids Surf B Biointerfaces. 2016 Dec 1;148:453-459.
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Author
- Barbosa SC, Nobre TM, Volpati D, Ciancaglini P, Cilli EM, Lorenz